Public Project
40 Years of Investment in Innovative Science - Pew Trust Magazine
"Dr. Mello’s work focuses on nematode worm Caenorhabditis elegans as a model organism in which to study the role of PIWI Argonaute (AGO) and other AGO pathways. Recently they have shown that worm PIWI AGOs use their piRNA cofactors to constantly scan the germline for foreign mRNA sequences. These memory small RNAs are loaded onto silencing AGOs that not only silence the foreign mRNA but are also transmitted to progeny in both the egg and the sperm, allowing progeny to maintain silencing. This mode of inheritance is not mediated by the DNA but by direct transmission of AGO/small-RNA complexes. Concluding that animals with exactly the same DNA content can transmit different patterns of gene expression to their offspring." - Pew
40 Years of Investment in Innovative ScienceIt’s been 40 years since the Pew Scholars Program in the Biomedical Sciences was founded in 1985. In that time, the program, the first in the organization’s history to carry the Pew name, has supported more than 800 outstanding young researchers,...
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